Category: Specialized Subjects, Credit : 1,
Intensive summer lecture, time: 10:30-17:50, September 17&18
Instructor: Adam Weitemier
Subtitle: Neurobiology of the locus coeruleus norepinephrine system
The locus coeruleus (the “blue spot”) is a small nucleus on either side of the vertebrate hindbrain. Its primary neurotransmitter
is norepinephrine (NE). Through extensive neuronal projections, NE output from the locus coeruleus influences fundamental
bodily functions, emotional responses, and cognition. Although the locus coeruleus NE system is the longest and most well-
studied neuronal system, current research continues to make new discoveries about its role in brain function and behavior.
This course will take a student-interactive approach to explore fundamental and current knowledge about the locus coeruleus
NE system. We will consider current topics and future questions through the lens of recent studies that are conducted from
different biological perspectives.
By taking thStudents taking this course will gain an understanding and perspective on the importance of NE (and related systems) in
physiology and behavior. They will be able to use the knowledge that they gain in this course to guide future learning about
the diversity of brain function.
Tentative Course Schedule
• Background lectures:
Anatomy, pharmacology and physiology of the Locus Coeruleus NE system (class activity)
Behavioral and Cognitive Theories of Locus Coeruleus NE function
• Research Paper I: A dynamic role of the locus coeruleus in emotion and learning
• Mid-course Assignment
• Class activity I: Assignment Review
• Research Paper II: NE and non-neuronal brain functions
out of class activity requirement
One mid-course assignment
Research articles to be distributed throughout the course
Attendance - 10%, Quiz - 30%, Assigned work - 30%, Participation - 30%
Available for questions/comments via KIBAKO online system
Required background knowledge
Knowledge in biology, basic physiology or neurobiology
For questions, email to Dr. Kanae Ando .